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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dapsone
supplement:
Glutathione
Research Papers that Mention the Interaction
“Incubation of … and dapsone hydroxylamine caused … in glutathione levels (98.3 +/- 1.6%) compared with red cells and dapsone hydroxylamine alone (84.8 +/- 2.7%) at 5 min (P < … there was no significant difference between the groups at 15 min (96.9 +/- 2.6 vs 98.1 +/- 2.2%).”
Reduction of dapsone hydroxylamine to dapsone during methaemoglobin formation in human erythrocytes in vitro.“Irreversible binding of dapsone to cells was significantly (P less than 0.05) reduced by omission of NADPH (85 +/- 13 pmol/10(6) cells) or addition of glutathione (103 +/- 9) compared with control values (153 +/- 51).”
“Red‐cell reduced glutathione GSH ) levels tended to be lower than normal, proportional to the dose of dapsone and GSH levels were unstable on incubation.”
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