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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dantrolene
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“3 days treatment with dantrolene , a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0.22 (0.05) mumol/L and accelerated patients' recovery.”
Myoplasmic Ca2+ concentration during exertional rhabdomyolysis“Drugs inhibiting intracellular calcium –induced calcium release, such as dantrolene , levetiracetam, and carisbamate, lowered OP SE–mediated protracted calcium elevations.”
“… calcium increase was blocked by the sarco/endoplasmic reticulum Ca(2+) pump inhibitor …, the inositol trisphosphate receptor inhibitor xestospongin D, and the ryanodine receptor inhibitors dantrolene and 1,1'-diheptyl-4,4'-bipyridinium dibromide, but not by removal of extracellular calcium, showing that WIN releases calcium from intracellular stores.”
“ Dantrolene inhibits the release of calcium and can halt the process if given before depletion of the energy rich phosphates is too advanced.”
“ Dantrolene diminishes the activation of the contractile process in muscle fibers by reducing the release of calcium ions from the sarcoplasmic reticulum.”
“Thus dantrolene inhibits twitch tensions of skeletal muscle fascicles, probably by indirectly preventing the release of calcium from the SR.”
“To a lesser extent dantrolene inhibits caffeine induced contractures of skeletal muscle fascicles, probably by indirectly accelerating the uptake of calcium into the SR.”
“ Dantrolene , which is able to effectively impede the abnormal flow of calcium from the sarcplasmic reticulum into the muscle cytoplasm, was beneficial to reduce the clinical symptoms of NMS.”
“Oral pharmacotherapy: (a) baclofen, binds GABAB receptors of spinal interneurons presynaptically, inhibits release of excitatory neurotransmitters in the spinal cord; (b) tizanidine, … of excitatory neurotransmitters in the spinal cord; (c) diacepam, augments GABA mediated inhibition in the spinal cord and supraspinally;(d) dantrolene, … calcium from sarcoplasmic reticulum … myofiber excitation.”
“ Dantrolene inhibits the release of calcium and can halt the process if the diagnosis is made early.”
“ Dantrolene , which inhibits the release of sequestered intracellular calcium , was also an effective blocker of the mitogenic stimulation of these growth factors.”
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