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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Danazol
supplement:
Progesterone
Research Papers that Mention the Interaction
“An improvement in the clinical symptoms, decrease in LH, FSH, estradiol and progesterone levels was produced by danazol.”
[Evaluation of danazol treatment of women with fibrocystic disease of breast].“These studies demonstrate that: (1) danazol prevents the midcycle surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH); (2) danazol does not significantly … to estrogen receptors; (6) danazol binds to sex hormone-binding globulin and corticosteroid-binding globulin; (7) danazol inhibits multiple enzymes of steroidogenesis; (8) danazol … progesterone; ….”
“ Danazol inhibited chorionic gonadotropin-stimulated progesterone production by pregnant rat luteal cells in vitro in a dose-dependent fashion.”
“Since danazol (30 microM) also inhibited progesterone production by human luteal cells in vitro and was dominant to the luteotrophic action of chorionic gonadotropin, it is suggested that danazol may have some potential as an interceptive agent in humans.”
“The progesterone resistance is counteracted by progestins (Medroxyprogesterone acetate, Dienogest, Danazol , Levonorgestrel) or by Selective progesterone receptor modulators, a class of drugs under development.”
“ Danazol was shown to significantly lower the duration of menses when compared with NSAIDs (WMD -1.0; 95% CI -1.8 to -0.3) and a progesterone releasing IUD (WMD -6.0; 95% CI -7.3 to -4.8).”
“ Danazol was shown to significantly lower the duration of menses when compared with NSAIDs (WMD -1.0; 95% CI -1.8, -0.3) and a progesterone releasing IUD (WMD -6.0; 95% CI -7.3, -4.8).”
“These findings suggest that danazol and progesterone in a superphysiological milieu down-regulate the intracellular SHBG-related steroidal actions, and that progesterone in a physiological milieu with estrogen up-regulates it in a hormone-dependent cell line.”
“There was a significant linear correlation between the inhibitory rates of PR binding capacity of progesterone and danazol.”
“The relationship between the growth inhibitory effect of progesterone and danazol showed a significant correlation for all points (r = 0.89, P less than 0.05).”
“ Danazol was selected in an attempt to suppress progesterone levels, theoretically by inhibiting ovulation.”
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