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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Daidzein and Topotecan

supplement:

Daidzein

Research Papers that Mention the Interaction

Combination treatment with DAI and TPT showed a strong synergistic effect on tumor cells, with a 0.10˜0.66 combined index, by increasing TPT inhibition on Topo Ⅰ, resulting in more cells arresting at the G2/M phase and inducing more cells to undergo apoptosis.
Moreover, the combination of DAI and TPT showed a stronger inhibitory effect (P < 0.01) on tumor growth in both MCF7 and MCF7/ADR xenograft models than the 9 mg/kg TPT monotherapy group.
Pharmacological research  •  2019  |  View Paper