Possible Interaction: Daidzein and Genistein

“It was found that the concentration of genistein in plasma was 3-fold higher than the plasma concentration of daidzein.”

“Use of soy isoflavone mixture has been advocated as an alternative, wherein daidzein can negate harmful effects of genistein.”

“Consumption of the soya isoflavones genistein and daidzein may provide protection against postmenopausal bone loss.”

“Ileal and faecal digestibility of genistein (93 and 99.9%, respectively) were significantly greater than that of daidzein (32 and 77.5%, respectively).”

“T47D:A18/PKCα tumor growth was partially stimulated by genistein , yet partially inhibited by daidzein.”

“Compared with daidzein, genistein exerted greater inhibitory effects for all parameters studied.”

“ Genistein and daidzein were complete agonists at both ERs, genistein being more potent than daidzein, and both compounds were more potent at ER beta than ER alpha.”

“Levels detected in human body fluids were found to be highly active at inhibiting neoplastic transformation, especially considering synergistic effects observed for combinations of daidzein and genistein , the predominant isoflavonoids occurring in soy foods.”

“RESULT(S) The ESC exposed to 0, 19, 20, 50, and 100 μM of ge istein, d aidzein, and genistein + dai dzein sh owed a dose-dependent proliferation decrease.”

“Cells were treated with varying concentrations of daidzein, genistein (25-200 μM) or their combinations (25 or 50 … cell proliferation, apoptosis, cell cycles and cellular uptakes of the isoflavones were measured after 48 h. Daidzein … genistein showed a synergistic effect on inhibiting cell … inducing apoptosis of both PCa cells.”

“Our results imply that (1) invasive activity is at least partially dependent on membrane fluidity, (2) genistein may exert its antimetastatic effects by changing the mechanical properties of prostate cancer cells and (3) daidzein should be applied at higher concentrations than genistein in order to achieve pharmacological effects.”