Possible Interaction: Dactinomycin and Vitamin K

“Publisher Summary This chapter discusses the concepts relating … mode of action of vitamin K. The actinomycin D , which blocks the DNA-dependent … polymerase, inhibited the action of vitamin K in stimulating the appearance of prothrombin complex in the blood … vitamin K-deficient chicks over a period of 6 hours.”

“Co-treatment with actinomycin D reduced the MQ induction of MIP-1α mRNA to a greater extent than the HO-induced increase.”

“Following administration of actinomycin D or ethionine to vitamin K-deficient rats, treatment with vitamin K1 markedly stimulated prothrombin production, indicating that the site of action of vitamin K is beyond the level of transcription of DNA to prothrombin messenger RNA.”

“It has been shown that actinomycin D inhibits vitamin K induced prothrombin formation in chicks deficient in vitamin K. Doses of actinomycin which inhibited the normal response to vitamin K inhibited incorporation of adenine-8-C14 into hepatic RNA.”

“ Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C14.”