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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Vitamin D
Research Papers that Mention the Interaction
“Small doses of mithramycin inhibit bone resorption; dactinomycin and other RNA inhibitors block the action of vitamin D in vitro.”
New approach to the treatment of hypercalcemia The effect of short‐term treatment with mithramycin“These protective effects of vitamin D3 were completely attenuated by intracerebroventricular injection of transcription inhibitor Actinomycin D and significantly inhibited by small interfering ribonucleic acid (siRNA) for vitamin D receptor and OPN in Pre-SAH + VitD3 rats.”
Intranasal administration of vitamin D attenuates blood–brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats“This suppression was observed within 24 h and lasted for at least 48 h. The … starting at 10(-9) mol/L and saturated at 10(-8) mol/L. The vitamin D3 suppression of HES-… blocked by actinomycin D as well as cycloheximide, suggesting the …, which requires new protein synthesis.”
“ Actinomycin D (intramuscular, 100 micrograms/200 g of body wt) together with ergocalciferol (120 micrograms/200 g of body wt) reduced protein kinase C activity by 51% 24 hr after injection.”
“The increase in alkaline phosphatase activity following simultaneous administration of vitamin D3 and zinc was significantly inhibited by treatment with cycloheximide, actinomycin D , or mitomycin C. Also, the increase in DNA content was completely inhibited by mitomycin C treatment.”
“Inhibition of vitamin D responses by actinomycin D suggests the involvement of gene activation in the sterol's action of raising intestinal transport activities.”
“ Actinomycin D or cycloheximide given in vivo reduces the 25-hydroxyvitamin D3 -24-hydroxylase activity rapidly which suggests that the turnover of the enzyme and its messenger RNA is rapid (1- and 5-h half-life, respectively).”
“A more recent alternative hypothesis suggested that actinomycin D blocked the biological response to calciferol by inhibiting the mandatory metabolism of cholecalciferol to 1,25-dihydroxycholecalciferol.”
“ Actinomycin D was found to inhibit calcium transport stimulated by cholecalciferol or its metabolites without inhibiting their metabolism or localization in the target tissue, the intestinal mucosa.”
“While the response of intestinal transport to physiological amounts of 25-hydroxycholecalciferol is blocked by actinomycin D , the response of intestinal calcium transport to 1,25-dihydroxycholecalciferol is insensitive to the antibiotic.”
“ Actinomycin D inhibited this vitamin D3 action in microsomes and supernatants.”
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