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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Tretinoin
Research Papers that Mention the Interaction
“Retinoids act either via the nuclear receptor retinoic acid receptor or retinoid X receptor, including all-trans retinoic acid (atRA), and panagonist 9-cis-retinoic acid-upregulated VSMC ADPR-cyclase; the stimulatory effect of atRA was blocked by actinomycin D and cycloheximide.”
ADP-Ribosyl cyclase in rat vascular smooth muscle cells: properties and regulation.“The induction of apoA-I mRNA by RA was completely blocked by actinomycin D , suggesting that RA acts at the transcriptional level in HepG2 cells.”
“It was found that the enhanced catabolism brought on by P450 induction was blocked when RA was added to AMC-HN-6 along with actinomycin D or cyclohexamide.”
“Moreover, we show that the induction by RA can be inhibited by actinomycin D , suggesting that the up-regulation may be mediated by a transcriptional mechanism.”
“Cycloheximide and actinomycin D blocked the action of RA , suggesting that RA may regulate transferrin and albumin gene expression indirectly in human liver cells.”
“The stimulation of HA synthesis occurs immediately after the addition of retinoid and cannot be prevented by pretreatment with actinomycin D, whereas the alterations in the pattern of keratin protein synthesis appear later and are inhibited by treatment with actinomycin D at or before the administration of retinoid.”
“ Actinomycin D , when added alone, only induced NBT positivity, but, when used in combination with retinoic acid , increased both NBT positivity and morphologically matured cells.”
“Pretreatment of cells with actinomycin D inhibited 2-5A synthetase induction by RA , suggesting that RA increased the transcription of the 2-5A synthetase gene.”
“Unexpectedly, the co‐addition of a low dose of ACD with RA further potentiated the upregulation of the LTC4 S activity.”
“While LTC4 S mRNA and protein increased in the cells treated with RA , the co‐addition of ACD further potentiated both in proportion to the LTC4 S activity.”
Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone“With added actinomycin D, RA did not affect the disappearance rate of RAR-beta mRNA, but SP-C mRNA degradation was slowed, indicating an effect on SP-C mRNA stability.”
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