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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Dactinomycin and Sulforaphane

drug:

Dactinomycin

supplement:

Sulforaphane

Research Papers that Mention the Interaction

“Nrf2 protein levels in both nuclear and whole cell lysates were increased after sulforaphane treatment and were decreased by pretreatment with NAC, actinomycin D and cycloheximide.”
Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2012  |  View Paper
“We show that TrxR1 mRNA, but not TrxR2 mRNA, is induced up to 4-fold by sulforaphane , and this increase was abolished by actinomycin D , a transcription inhibitor.”
Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.
Carcinogenesis  •  2003  |  View Paper