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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“ Actinomycin D (5x10(-6) M), an inhibitor of transcription, abolished the incorporation of [14C] phenylalanine and the increased protein mass elicited by endothelin-1 (10(-8) M).”
Use of A-192621 to provide evidence for involvement of endothelin ET(B)-receptors in endothelin-1-mediated cardiomyocyte hypertrophy.“This falling phase was insensitive to … propionamide inhibitor, but application of actinomycin D resulted in … increase in phenylalanine ammonia-lyase activity (superinduction) after 12 h. Superinduction by actinomycin D suggests that availability of phenylalanine ammonia-lyase mRNA for translation may be controlled to produce the change in enzyme activity.”
Induction by hormones of phenylalanine ammonia-lyase in bean-cell suspension cultures. Inhibition of superinduction by actinomycin D.“ Actinomycin D , 6-methylpurine, and cycloheximide all inhibited the formation of phenylalanine ammonia-lyase, though cycloheximide was the most effective at low concentrations.”
“When actinomycin D or cycloheximide was added at different times after the onset of light, characteristic differences in the inhibitory effects on the increases in phenylalanine ammonia-lyase activity were observed.”
“Administration of cycloheximide or actinomycin D at an early period almost completely suppressed the increase in phenylalanine ammonia-lyase activity.”
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