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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Orotic Acid
Research Papers that Mention the Interaction
“…)Actinomycin D inhibited the incorporation of 14 C from [ 14 C]-formate, [1- 14 C]-glycine, […, [8- 14 C]guanine, [2- 14 C]2,6-diaminopurine, and [6- 14 C]orotic acid into RNA more than into DNA, and in a … was inhibited more than the incorporation into adenine.”
Studies related to the mode of action of actinomycin D.“Exposure of chick embryos to actinomycin D (0.05 micrograms/ml) at the primitive streak stage (stage 4; Hamburger and Hamilton) for 6 h showed interference in orotic acid formation.”
Dihydroorotic acid dehydrogenase activity in actinomycin-D-treated and normal chick embryos.“The inhibition of the [2-14C] orotic acid incorporation into rapidly labelled RNA by actinomycin D is substantially less expressed in the thymus than in the liver.”
“ Actinomycin D (10 μg/ml) reduced the incorporation of labelled orotic acid into the 45–55-S RNA approx.”
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