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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Dactinomycin and Glutathione

supplement:

Glutathione

Research Papers that Mention the Interaction

glutathione caused DNA cleavage … addition of ActD enhanced the DNA cleavage at the sites at which the lesions on opposite strands are staggered 2 bases in a 3' …'-TGT-3'.3'-ACA-5' and 5'-ACT-3'.3'-TGA-5' sequences, suggesting that ActD amplified double-stranded DNA cleavage.
Biochemical and biophysical research communications  •  1997  |  View Paper
Actinomycin-D partially prevented the cobalt-stimulated rise in hepatic GSH.
The Journal of pharmacology and experimental therapeutics  •  1978  |  View Paper
We found that ActD caused HepG2 cell necroptosis characterized by DNA fragmentation, decreased mitochondrial membrane potential, cytochrome c depletion, and decreased the levels of reduced glutathione.
Pharmaceuticals  •  2021  |  View Paper