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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Glutathione
Research Papers that Mention the Interaction
“… glutathione caused DNA cleavage … addition of ActD enhanced the DNA cleavage at the sites at which the lesions on opposite strands are staggered 2 bases in a 3' …'-TGT-3'.3'-ACA-5' and 5'-ACT-3'.3'-TGA-5' sequences, suggesting that ActD amplified double-stranded DNA cleavage.”
Actinomycin D amplifies site-specific DNA cleavage induced by neocarzinostatin.“ Actinomycin-D partially prevented the cobalt-stimulated rise in hepatic GSH.”
Paradoxical effects of cobaltous chloride and salts of other divalent metals on tissue levels of reduced glutathione and microsomal mixed-function oxidase components.“We found that ActD caused HepG2 cell necroptosis characterized by DNA fragmentation, decreased mitochondrial membrane potential, cytochrome c depletion, and decreased the levels of reduced glutathione.”
Actinomycin D Arrests Cell Cycle of Hepatocellular Carcinoma Cell Lines and Induces p53-Dependent Cell Death: A Study of the Molecular Mechanism Involved in the Protective Effect of IRS-4
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