Possible Interaction: Dactinomycin and Glucose

“In this period, the presence of the transcriptional inhibitor actinomycin D revealed a significant protective effect of excess glucose on mature PPAR-gamma1 and PGC-1alpha mRNAs.”

“ Actinomycin-D and cycloheximide strongly suppressed the stimulatory effect of glucose on secretion of both apolipoproteins.”

“FAS mRNA stability as determined by actinomycin D chase was 7-fold greater in the presence of glucose.”

“Northern analysis of VSMC poly A+ RNA revealed that high glucose induced a threefold increase in Na+/H+ antiport (NHE-1) mRNA at 24 h. Inhibiting this increase in NHE-1 mRNA with actinomycin D prevented the sustained glucose-induced increase in Na+/H+ antiport activity.”

“In the presence of 1 microgram/ml actinomycin D , the increase in the expression of AR mRNA level by glucose was almost completely abolished, suggesting its transcriptional regulation by glucose.”

“Inhibition of RNA synthesis by actinomycin D prevented the down‐regulatory effect of glucose.”

“In addition to their roles on the production of these mRNAs, glucose and insulin on the one hand and glucagon … of the L-type pyruvate kinase messengers: the half-life of the mRNA whose production has been blocked by actinomycin D is 1 h in … the presence of glucose ….”

“ Actinomycin D inhibited chitin synthesis in the eggs from the distal half of the uterus and it significantly reduced incorporation of radiocarbon from glucose into chitin.”

“When glucose and actinomycin D are administered in association at birth or 13 hours after birth, actinomycin D overcomes the inhibitory effect of glucose on ornithine transcarbamylase activity and decreases insulinemia at the level found in normal neonate.”

“Glucose‐induced deactivation of transport activity was also prevented by cycloheximide or actinomycin D addition concomitantly with glucose.”