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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Edetic Acid
Research Papers that Mention the Interaction
“Cells grown in the presence of EDTA were abnormally sensitive to actinomycin D and showed reduced uptake of 3H-uracil into acid-insoluble products.”
Metallo-enzymes released from Escherichia coli by osmotic shock. I. Selective depression of enzymes in cells grown in the presence of ethylenediaminetetraacetate.“The EDTA treatment (1) promoted the loss of amino acids and materials absorbing at 260 mμ from the mycelium, (2) increased the sensitivity of induction to inhibition by actinomycin D , (3) inhibited the uptake of lysine and uridine from the induction buffer and (4) inhibited the synthesis of protein.”
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