supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Dactinomycin
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ DACT (… ACTH (1.3-fold), CORT (2.9-fold) and progesterone (1.9-fold) above vehicle control concentrations, but the magnitude of the responses was much … an equal molar dose of ATR (200 mg/kg; 7.0, 9.0 and 11.0-fold above ACTH, CORT, progesterone controls, respectively).”
Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidance.“ Actinomycin D and cycloheximide completely blocked the effect of ACTH on HO-1 mRNA expression whereas mRNA stability was not affected by ACTH.”
“The effect of ACTH on the p43 transcript was inhibited by actinomycin D and enhanced by cycloheximide.”
“ Actinomycin D , when injected in vivo 1h before or after corticotropin injection, prevents the effect of corticotropin on protein E synthesis, which is interpreted as evidence that mRNA synthesis is necessary for the stimulation of protein E synthesis.”
“When injected more than 2h after corticotropin, actinomycin D does not prevent corticotropin stimulation of protein E synthesis, but completely blocks corticotropin stimulation of total protein synthesis.”
“ Actinomycin D , as well as dexamethasone, blocks only the DNA synthesis-promoting action of ACTH.”
“ Actinomycin D given during the first 3 h after ACTH in the 16 h hypophysectomized rat abolished the expected increase in ornithine decarboxylase activity.”
“Thereafter, a progressive increase in ornithine decarboxylase activity was observed as the interval between ACTH and Actinomycin D administration was further increased.”
“The regenerative effect of ACTH is blocked by actinomycin D but not by puromycin, indicating that an RNA factor is involved.”
“Abstract Under in vitro superfusion conditions, actinomycin-D potentiates the steroidogenic effect of ACTH and delays the onset of the refractory state in the rat adrenal gland.”
“ Actinomycin D and puromycin inhibited this transformation if they were added with ACTH.”
“ Actinomycin D was found to abolish completely the in vitro steroidogenic effect of ACTH during incubations of cow adrenal slices.”
“The inhibitory effects of actinomycin D were reversible and were evident only if the antibiotic was present during the preincubation and incubation with ACTH.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback