“CONCLUSION Collectively, combined treatment with AT A an d dac arbazine in duced more apoptosis and enhanced the cell cycle arrest of CD117+ melanoma cells.”
“Here, we aim to improve response to dacarbazine therapy by pretreatment with all-trans retinoic acid (ATRA) in CD117+ melanoma cells.”
“There was an indication that the combination of ATRA with dacarbazine (ATRA/dacarbazine) caused more apoptosis and necrosis in the melanoma cells (P<0.05).”
“These results suggested that ATRA increased the sensitivity of melanoma cells to the effect of dacarbazine.”