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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Dacarbazine
supplement:
Cupric Cation
Research Papers that Mention the Interaction
“Electron spin resonance (ESR) spin-trapping experiments were performed to … radical species generated from UVA-irradiated DTIC.ResultsUVA-irradiated DTIC caused DNA damage at guanine residues, especially at the 5′-GGT-3′ sequence in the presence of Cu(II) and also induced 8-oxodG generation in calf thymus DNA.”
Mechanism of UVA-dependent DNA Damage Induced by An Antitumor Drug Dacarbazine in Relation to its Photogenotoxicity“The interaction of Dac with dsDNA in the presence of Cu(II) leads to a much stronger intercalation.”
Binding mode and thermodynamic studies on the interaction of the anticancer drug dacarbazine and dacarbazine-Cu(II) complex with single and double stranded DNA.
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