Possible Interaction: Cysteine and Vitamin C

“During ingestion of ascorbic acid , the mean excretion of cysteine by the control group increased from 134.1 to 159 μmol/ day, whereas the excretion of cystine decreased from 107.1 to 82 μmol/day.”

“These results suggest a new role for high concentrations of vitamin C in modulation of intracellular sulfur containing compounds, such as glutathione and cysteine.”

“A “redoxome” approach revealed that AA treatment altered the redox state of key antioxidants and a number of cysteine-containing proteins including many nucleic acid binding proteins and proteins involved in RNA and DNA metabolisms and in energetic processes.”

“ Vitamin C is known to increase the in vitro conversion of amygdalin to cyanide and reduce body stores of cysteine , which is used to detoxify cyanide.”

“The molar cysteine percentage of cysteine in healthy persons is increased from 30 to 50% by oral ascorbic acid administration.”

“ Cysteine seemed to have a sparing effect when it was added with ascorbic acid.”

“These observations also suggest that treatment with vitamins C and E improves glutathione synthesis by enhancing the influx rate of L-cysteine through the modification of membrane proteins and lipids.”

“ Vitamin C can increase tissue cysteine and glutathione levels.”

“A combination with 15 mg/kg of tartaric acid, citric acid, L-aspartic acid or L-cysteine also increased the AUC, byt they were less effective than ascorbic acid.”

“Adding ascorbic acid to incubations containing acetaminophen and cysteine markedly decreased acetaminophen-cysteine adduct formation.”

“ Ascorbic acid addition to aqueous incubations containing N-hydroxyacetaminophen and cysteine similarly inhibited the nonenzymatic formation of an acetaminophen-cysteine adduct.”