Possible Interaction: Cysteine and Tyrosine

“Other substances found to inhibit the iodination of tyrosine by the thyroid particulate fraction are DPNH, TPNH, cysteine , epinephrine, norepinephrine, serotonin, ergothioneine, thiohistidine and dichlorophenol.”

“The substitution of tyrosine with cysteine would affect the structure of the pore region, resulting in the loss of channel function.”

“We also describe a case of heterozygosity for both the substitution of tyrosine with cysteine at position 282 and the substitution of histidine to aspartic acid at position 63 (so-called "compound heterozygosity").”

“The tyrosine phosphorylation was also inhibited by exogenous glutathione or cysteine and could be enhanced by depletion of cellular glutathione by BSO.”

“Dopa and/or tyrosine protects tyrosinase against inactivation by cysteine.”

“ Cysteine inhibited it more efficiently than histidine, methionine, tryptophan, tyrosine or alanine under the conditions used.”

“Due to the synergetic effect between Cys and the Au NPs, the characteristic Raman scattering intensities of the Tyr (or Phe) enantiomer with the same chirality of Cys are enantioselectively boosted by over four-fold compared with those of the counter enantiomer of Tyr (or Phe).”

“We conclude that redox coupling between tyrosine and cysteine can act as a PCET control mechanism in proteins.”

“Crystallography shows that when un-crosslinked, the cysteine thiol excludes tyrosine 159 from its native position, while kinetic analysis shows that the thioether bond impairs reactivity of the crosslinked form.”

“Results indicated that only amino acids of tryptophan, cysteine and histidine are photoactive and possess potential interferences in analysis of Tyr.”