Possible Interaction: Cysteine and Tryptophan

“Substitution of half-cystinyl residues by tryptophan resulted in increased activities, while other substitutions did not change activity.”

“Development and/or mean cell number were significantly inhibited by the presence of leucine, tyrosine, valine, isoleucine, phenylalanine, arginine, methionine, or cysteine (at 0.5 mM) and isoleucine, phenylalanine, or tryptophan (at 0.05 mM).”

“ Cysteine inhibited it more efficiently than histidine, methionine, tryptophan , tyrosine or alanine under the conditions used.”

“In all proteins, the tryptophan residues undergo strong static and dynamic quenching, probably due to charge-transfer interactions with the nearby sulfur atoms of the active cysteines.”

“Perturbation of the cysteines and/or tryptophans results in concomitant decreases in enzymic activity.”

“ Tryptophan increased the enzyme activity and cysteine had the opposite effect.”

“Addition of excess cysteine to the diet masked the effects of gelatin and tryptophan , stimulated glutathione synthesis in the liver as well as incorporation of dietary cysteine into protein fractions.”

“The feeding of l-tryptophan (0.5 per cent) plus l-cysteine (0.1 per cent) led to a significant reduction in the incidence of tumors from 63 per cent to 24 per cent and in the incidence of erupt eyes from 52 per cent to 7 per cent.”

“The toxicity of tryptophan , during the pupal stage, was greatly reduced when cysteine was added to the medium.”

“In this study, it was found that indirubin production greatly increased when 0.36g/L cysteine was added to the tryptophan medium , although cysteine inhibited the growth of the recombinant E. coli harboring the fmo gene.”

“ Tryptophan and cysteine converged slightly faster in W(15)C(162) (β(1)β(8), trans) than in W(7)C(170) (β(1)β(8), cis).”