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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
drug:
Thimerosal
Research Papers that Mention the Interaction
“These results suggest that thimerosal interacts with the cysteine residue C214 in the S3 segment of KCNQ1, leading to a change of its gating properties.”
The Oxidant Thimerosal Modulates Gating Behavior of KCNQ1 by Interaction with the Channel Outer Shell
“ Thimerosal reacted rapidly with cysteine , GSH, human serum albumin, and single-stranded DNA to form ethylmercury adducts that were detectable by mass spectrometry.”
“This demonstrates that thimerosal interacts directly with cysteine in both the SD and IBC.”
Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain“ L-Cysteine significantly attenuated the actions of thimerosal to reduce the glutathione content and to increase the intracellular Ca2+ concentration.”
“Moreover, the inhibitory effect of thimerosal on the nitrergic, ACh- or GTN-induced relaxations were partly reversed by sulfhydryl-containing compounds, L-cysteine (10(-3) M), dithiothreitol (10(-3) M), or glutathione (10(-3) M).”
“In both young adult and aged rat fibers the effect of thimerosal was reversed only by addition of L-cysteine.”
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