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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Cysteine and Tegafur

supplement:

Cysteine

drug:

Tegafur

Research Papers that Mention the Interaction

The dose ratio of l-cysteine or l-cystine to FT needs 5 by weight to potentiate the antitumor activity of FT.
Journal of Cancer Research and Clinical Oncology  •  2004  |  View Paper
Higher plasma concentrations of 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) were obtained after administration of FT (100 mg/kg, i.v.) combined with L-cysteine (CySH, 500 mg/kg, p.o.).
Japanese journal of pharmacology  •  1990  |  View Paper
In sarcoma 180 bearing mice, the oral antitumor activity of FT in combination with L-CYS (500 mg/kg, i.p. or p.o.) was about 1.1-2.0 times higher than that of FT alone.
It was concluded from these findings that the drug metabolizing enzymes in liver involved … FT into an active metabolite, 5-FU, are influenced by the combined administration of FT … L-CYS to give an increased organ level of 5-FU; … in the enhancement of the antitumor activity of FT.
On the other hand, the oral acute toxicity of FT was also enhanced with the combined administration of FT and L-CYS.
The plasma and liver concentrations of both 1-(tetrahydro-2-furanyl)-5-fluorouracil (FT) … (5-FU), an active metabolite of FT, increased very markedly after administration of FT (500 mg/….) combined with L-cysteine (L-CYS, 500 mg/kg, i.p. or ….) when compared to FT alone in rats.
Japanese journal of pharmacology  •  1983  |  View Paper