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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Cysteine and Tegafur

supplement:

Cysteine

drug:

Tegafur

Research Papers that Mention the Interaction

The dose ratio of l-cysteine or l-cystine to FT needs 5 by weight to potentiate the antitumor activity of FT.
Journal of Cancer Research and Clinical Oncology  •  2004  |  View Paper
In sarcoma 180 bearing mice, the oral antitumor activity of FT in combination with L-CYS (500 mg/kg, i.p.
It was concluded from these findings that the drug metabolizing enzymes in liver involved … FT into an active metabolite, 5-FU, are influenced by the combined administration of FT … L-CYS to give an increased organ level of 5-FU; … in the enhancement of the antitumor activity of FT.
On the other hand, the oral acute toxicity of FT was also enhanced with the combined administration of FT and L-CYS.
Japanese journal of pharmacology  •  1983  |  View Paper