“In sarcoma 180 bearing mice, the oral antitumor activity of FT in combination with L-CYS (500 mg/kg, i.p.”
“It was concluded from these findings that the drug metabolizing enzymes in liver involved … FT into an active metabolite, 5-FU, are influenced by the combined administration of FT … L-CYS to give an increased organ level of 5-FU; … in the enhancement of the antitumor activity of FT.”
“On the other hand, the oral acute toxicity of FT was also enhanced with the combined administration of FT and L-CYS.”