Possible Interaction: Cysteine and Sulfur

“Results: Dietary total SAAs and cysteine of overweight/obese participants were significantly higher.”

“It is thought that sulfur interacts with cysteine present in the stratum corneum to form hydrogen sulfide; however, its precise mechanism of action is unknown.”

“These studies demonstrate that methionine is not a superior substrate to cysteine for hepatic glutathione synthesis and that cysteine concentration (presumably intracellular cysteine concentration) has a major effect on the partitioning of cysteine sulfur to taurine in rat hepatocytes.”

“Unique protein microenvironments favor the polarization of sulfur , thus increasing the overt reactivity of cysteine.”

“Based on these results, we propose that the transport of cysteine plays a pivotal role in regulating cellular cysteine biosynthesis as well as modulating the availability of sulfur for mitochondrial metabolism.”

“Thus, the direct biosynthesis of cysteine from sulfide is the only pathway of synthesizing … in H. polymorpha, despite the presence of both directions of transsulfuration pathway Moreover, only cysteine , but no other sulfur amino … expression of a subset of sulfur genes , suggesting its central and … H. polymorpha sulfur metabolism.”

“Furthermore, since sulfur assimilation is highly regulated, genes coding for numerous transporters, key enzymes involved in sulfate assimilation and the interconversion of cysteine to methionine pathways are repressed under conditions of high sulfur supply.”

“It is suggested that the function of this sulfur cycle may be regulation of the free cysteine pool.”

“This study demonstrates that cysD and cysNC orthologues exist in M. tuberculosis and constitute an operon whose expression is induced by sulfur limitation and repressed by the presence of cysteine , a major end-product of sulfur assimilation.”

“Its synthesis was induced by sulfur limitation and strongly repressed by cysteine.”