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“Electrophysiological analysis shows that in the mutant cysteine , transport has become electroneutral, and its interaction with the countertransported potassium is impaired.”
The Journal of Biological Chemistry • 2000 | View Paper
“The interplay between Cat K and Cys C may underlie the progression of plaques from stable to unstable and the current study indicated that Cat K and Cys C are potential targets for preventing and treating vulnerable atherosclerotic plaque ruptures.”
Experimental and therapeutic medicine • 2017 | View Paper
“Substitution of Ser457 with alanine or cysteine decreases the rates of reduction of the substrates cytochrome c and potassium ferricyanide approximately 100-fold, while substitution with threonine produces a 20-fold decrease in activity.”