Possible Interaction: Cysteine and Phenylalanine

“The substitution of cysteine at amino acid position 227 with phenylalanine residue causes the rupture of a disulphide bond, giving rise to an aromatic ring, as shown by a molecular modelling analysis (Figure 1, panel b).”

“The concentrations in the plasma of phenylalanine rose seven-fold to a maximum observed at 22 hr and of cysteine rose almost threefold in 98 hr.”

“Two phenylalanines reorient sufficiently to shield/unshield the cysteine from the intracellular and extracellular ends, depending on the proton positions, and a tyrosine forms a hydrogen bond to the cysteine sulfur with its side chain –OH.”

“ L-Cysteine and L-phenylalanine enhanced acid-augmented duodenal HCO(3)(-) secretion.”

“The FRR ofl-methionine andl-phenylalanine was slightly reduced in the presence of cys.”

“N‐Acetyl‐l‐cysteine (AC), alanine, β‐alanine, cysteine sulphinic acid (CSA), γ‐aminobutyric acid (GABA),d‐phenylalanine, phenylalanine , serine and taurine inhibited MeHg– cysteine uptake at 5°C.”

“ L-cysteine inhibited strongly both ALPs, but inhibitory effects of L-phenylalanine , L-homoarginine, and L-leucine were undetectable for s-ALP and very weak for m-ALP.”

“Transport of L-cysteine is inhibited by L-alanine and L-phenylalanine but not by L-glutamic acid and the L-basic amino acids.”

“Abstract Ala, Cys , and Ser inhibited rat intestinal transport of 1 m m Phe in vivo when simultaneously present in concentrations of 10 m m or higher.”

“Due to the synergetic effect between Cys and the Au NPs, the characteristic Raman scattering intensities of the Tyr (or Phe ) enantiomer with the same chirality of Cys are enantioselectively boosted by over four-fold compared with those of the counter enantiomer of Tyr (or Phe).”