Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 months ago

Possible Interaction: Cysteine and Omeprazole

supplement:

Cysteine

Research Papers that Mention the Interaction

Our results demonstrate that omeprazole inhibits giardial triosephosphate isomerase in a species-specific manner through interaction with cysteine at position 222.
Antimicrobial agents and chemotherapy  •  2014  |  View Paper
Some PPIs, such as omeprazole and rabeprazole bind to cysteines that are exposed, and their binding can be reversed.
Pediatric Drugs  •  2013  |  View Paper
However, the deduced amino acid sequences of the amplification refractory mutation system (ARMS) PCR product of the AcrR gene revealed that the substitution of arginine to cysteine at position 45 of AcrR was observed only in the MDR E. coli whose antibiotic susceptibility increased in the presence of omeprazole.
  •  2019  |  View Paper
The introduction of cysteine at various locations within this region only marginally affected omeprazole sensitivity , suggesting that this region was not a direct site of covalent modification.
Biochimica et biophysica acta  •  1997  |  View Paper
The omeprazole sulfenamide , for example, reacts covalently with two cysteines in the extracytoplasmic loops between the fifth and sixth transmembrane and the seventh and eighth transmembrane segments of the α subunit of the H+,K+-ATPase, forming disulfide derivatives.
Digestive Diseases and Sciences  •  1995  |  View Paper
However, the deduced amino acid sequences of the amplification refractory mutation system (ARMS) PCR product of the AcrR gene revealed that the substitution of arginine to cysteine at position 45 of AcrR was observed only in the MDR E. coli whose antibiotic susceptibility increased in the presence of omeprazole.
British Journal of Cancer  •  2019  |  View Paper
Of interest, subsequent exposure of the stomach to a mercaptane compound cysteine , 100 mg/kg) for 30 min significantly reversed the antisecretory effect of omeprazole (both i.d.
Japanese journal of pharmacology  •  1988  |  View Paper
Biological reducing agents like cysteine or glutathione, however, were unable to reverse the inhibitory effect of omeprazole.
The Journal of biological chemistry  •  1985  |  View Paper