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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cysteine and Oltipraz

supplement:

Cysteine

Research Papers that Mention the Interaction

Oral coadministration of oltipraz , an antischistosomal compound, with cysteine to green monkeys (Cercopithecus aethiops) led to a marked increase in both the extent and rate of oltipraz bioavailability.
The marked increase in oltipraz bioavailability produced by coadministration of cysteine , irrespective of the exact mechanisms involved, may have significant clinical implications with regard to the treatment of schistosomiasis.
When 6 healthy adult animals were given oltipraz together with cysteine in a crossover study, peak serum concentrations, areas under the curve and absorption rate constants of oltipraz were on average 7 times greater than when the drug was administered alone.
Chemotherapy  •  1984  |  View Paper
By contrast, administration of L-cysteine is synergistic with the antischistosomal effect of oltipraz.
Research communications in chemical pathology and pharmacology  •  1982  |  View Paper