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Last Updated: 2 years ago

Possible Interaction: Cysteine and Nitroglycerin

supplement:

Cysteine

Research Papers that Mention the Interaction

The addition of captopril or L-cysteine (1 x 10(-6) M) enhanced the activity of both nitroglycerin and nicorandil, whereas addition of enalaprilat did not.
Journal of cardiovascular pharmacology  •  2000  |  View Paper
Liberation of nitric oxide (NO) from GTN and SPM 3672 measured in vitro was rather low and was markedly potentiated by addition of cysteine only in the case of GTN.
Pronounced activation of a partially purified human soluble guanylate cyclase (sGC) by GTN was observed only after addition of cysteine , whereas a comparative activation by SPM 3672 occurred with and without addition of this thiol.
Journal of cardiovascular pharmacology  •  1993  |  View Paper
N-Acetylcysteine, L-cysteine , and D-cysteine accelerated NTG degradation in whole blood, while a similar concentration of glutathione had no effect.
Journal of pharmaceutical sciences  •  1989  |  View Paper
Our results indicated that neighboring Cys and Tyr residues can facilitate each other's oxidation in the presence of NTG.
Rapid communications in mass spectrometry : RCM  •  2011  |  View Paper
The observed increase in formazan production and HMPS activity and the reduction of cell proliferation due to RA were augmented by co-treatment with either glyceryl trinitrate , molsidomine, CAS 936 or tetranitromethane plus cysteine.
Leukemia research  •  1995  |  View Paper
Cysteine (1 mM) enhanced cyclic GMP formation induced by sodium nitroprusside and nitroglycerin.
Pharmacology & toxicology  •  1992  |  View Paper
Preincubation of platelets with cysteine did not or only slightly increase the ability of isosorbide-5'-mononitrate and isosorbide dinitrate to inhibit aggregation, but a clear increase was observed after preincubation with nitroglycerin.
Thrombosis research  •  1988  |  View Paper
Cysteine appears to be particularly effective in potentiating guanylate cyclase activation by NTG.
Circulation  •  1983  |  View Paper
L-cysteine and NAC … relaxations to GTN (0.1 nM-10 microM) as the GTN relaxation EC50 decreased compared with that of the untreated RTCS (L-cysteine, 0.….12 microM and NAC, 0.08 +/- 0.03 microM versus control 0.25 +/- 0.08 microM, n = 5, p < 0.05).
Canadian journal of physiology and pharmacology  •  1997  |  View Paper
Previous studies have shown the effect of nitroglycerin on coronary microvessels < 100 microns in diameter is markedly enhanced by L-cysteine.
The American journal of physiology  •  1994  |  View Paper
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