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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cysteine and Nicorandil

supplement:

Cysteine

Research Papers that Mention the Interaction

The addition of captopril or L-cysteine (1 x 10(-6) M) enhanced the activity of both nitroglycerin and nicorandil , whereas addition of enalaprilat did not.
Journal of cardiovascular pharmacology  •  2000  |  View Paper
Each of the organic nitrate esters (1 microM to 1 mM) except nicorandil stimulated soluble GC activity in the presence of 10 mM cysteine.
The Journal of pharmacology and experimental therapeutics  •  1991  |  View Paper
These results give further evidence that a) nicorandil exerts its vasodilating effect via stimulation of guanylate cyclase and b) nitrate esters, such as nitroglycerin or nicorandil , stimulate the enzyme, at least in vitro, only in the presence of cysteine or, to a lesser extent, thiosalicylic acid.
Journal of cyclic nucleotide and protein phosphorylation research  •  1985  |  View Paper