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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
drug:
Nicorandil
Research Papers that Mention the Interaction
“The addition of captopril or L-cysteine (1 x 10(-6) M) enhanced the activity of both nitroglycerin and nicorandil , whereas addition of enalaprilat did not.”
Effect of angiotensin-converting enzyme inhibitors and nitroxy groups on human coronary resistance vessels in vitro.“Each of the organic nitrate esters (1 microM to 1 mM) except nicorandil stimulated soluble GC activity in the presence of 10 mM cysteine.”
Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters.“These results give further evidence that a) nicorandil exerts its vasodilating effect via stimulation of guanylate cyclase and b) nitrate esters, such as nitroglycerin or nicorandil , stimulate the enzyme, at least in vitro, only in the presence of cysteine or, to a lesser extent, thiosalicylic acid.”
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