Possible Interaction: Cysteine and Leukotriene D4

“Incubation of cultured or isolated human tracheal epithelial cells with LTD4 resulted in the formation of LTE4, which was completely blocked by pretreatment with L-cysteine (3 x 10(-3) M).”

“EDTA and L-cysteine inhibited the metabolism of leukotriene D4.”

“In the presence of L‐cysteine (5 mM), the metabolism of [3H]‐LTD4 into [3H]‐LTE4 was inhibited and the LTD4‐induced contractions were inhibited by the CysLT1 receptor antagonist ICI 198,615 (1–10 nM) with a pA2‐value of 9.3±0.2.”

“The responses to leukotriene C4 and leukotriene D4 were markedly potentiated when their metabolism was inhibited by S-hexyl glutathione and L-cysteine.”

“ L-Cysteine (3 mM; an inhibitor of an aminopeptidase, which prevents the conversion of LTD4 to LTE4) enhanced the contractile responses to LTD4.”

“L-Serine borate (45 mM), an inhibitor of gamma-glutamyl transpeptidase, shifted … dose-response curve of LTC4 to the left by 161-fold, and L-cysteine (6 mM), an inhibitor of aminopeptidase, shifted … dose-response curves of LTC4 and LTD4 to the left by 67- and 23-fold, respectively.”

“Addition of L-cysteine resulted in accumulation of LTD4.”

“In addition, LTD4 inactivation by AM and their supernatants was inhibited by 10 mM L-cysteine.”

“ L-Cysteine (3 mM) enhanced the contractile activity of both LTC4 and LTD4.”

“ L-Cysteine (3mM) enhanced the contractile activity of LTC4 and LTD4.”

“ L-Cysteine , an inhibitor of aminopeptidase, prevents the formation of LTE4 from LTD4 and LTC4.”