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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
drug:
Kynurenic Acid
Research Papers that Mention the Interaction
“On the contrary, thiol-containing compounds, L-cysteine and L-methionine, were only inhibiting kynurenic acid production.”
Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.“Therefore, the overall level of keto acids and cysteine might modulate the KYNA synthesis.”
“Thus, L-cysteine sulphinate might act as a modulator of KYNA formation in the brain.”
“Although injection of L-cysteine into the NTS produced responses similar to those seen with injection of L-S-nitrosocysteine, blockade of excitatory amino acid receptors with kynurenic acid inhibited responses to cysteine but not those to the nitrosothiol.”
“Ten out of 19 amino acids (specifically, leucine, isoleucine, phenylalanine, methionine, tyrosine, alanine, cysteine , glutamine, glutamate, and aspartate) significantly reduced KYNA formation at 1 mmol/L. These amino acids showed inhibitory effects in a dose-dependent manner, and partially inhibited KYNA production at physiological concentrations.”
Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro
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