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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
supplement:
Isothiocyanate
Research Papers that Mention the Interaction
“We hypothesize that ITCs , as electrophiles, can interact with the catalytic triads ( CYS , HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities.”
Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells“Mass spectrometry demonstrated that cysteines in tubulin were covalently modified by ITCs.”
“Herein, we reported that isothiocyanates (ITCs, R-NCS) rapidly formed adducts with cysteine.”
Isothiocyanates as H2S Donors Triggered by Cysteine: Reaction Mechanism and Structure and Activity Relationship.“For example, a reaction of ITC with nucleophilic amino acid side chains of proteins such as cysteine and lysine can occur, reducing the bioavailability of indispensable amino acids and protein functions may be altered.”
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