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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“We discovered that the combination of cysteine or other small thiols with either isoniazid or rifampicin prevents the formation of drug-tolerant and drug-resistant cells in Mtb cultures.”
Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis“These findings are interpreted in the light of the hypothesis that in INH intoxication there may be a reduction of available axonal glutathione and cysteine due to inhibition of the pyridoxal phosphate-dependent enzymes cystathionine synthetase and cystathioninase.”
“We had previously shown that cysteine , a derivative of NAC, potentiated the activity of isoniazid , a first-line TB drug, by preventing the emergence of INH resistance and persistence in M. tuberculosis in vitro.”
The Promises and Limitations of N-Acetylcysteine as a Potentiator of First-Line and Second-Line Tuberculosis Drugs
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