Possible Interaction: Cysteine and Iron, Dietary

“Recently, we showed that cysteine , in the presence of iron , promotes arginase activity by driving the Fenton reaction.”

“ Iron uptake from the "low citrate" formula plus cysteine was 102% greater relative to the nontreated formula.”

“The cysteine at position 90, which is located at the end of the BC-loop, appeared to be critical for the formation of ferritin aggregates during iron loading.”

“When LDL … oxidized by iron in the … of cysteine in either Hanks' balanced salt solution (HBSS) or Ham's F-10 medium, an acidic pH greatly decreased the lag … and increased the rate of formation of hydroperoxides and thiobarbituric acid-reactive substances (TBARS), and increased its uptake by macrophages.”

“Accumulated cysteine may chelate iron , accounting for the local increase in iron content in Hallervorden‐Spatz disease.”

“The combined excess of cysteine and ferrous iron may generate free radicals that damage neuronal membranes to cause the typical morphological changes observed in this disorder.”

“ Cysteine significantly increases, about 2-fold, the absorption from nonheme iron present in vegetable foods, hemosiderin, and of a ferric salt, when this amino acid is administered during the ingestion of foods.”

“is readily reduced by cysteine in the presence of iron or hemoglobin as a catalyst.”

“ L-cysteine increased the transfer of iron of both sources.”

“In particular, the two cysteines coordinating this iron appear to have substantially different bond strengths.”

“However, the cytoplasmic level of l-cysteine must be tightly regulated due to its propensity to reduce iron and drive damaging Fenton chemistry.”