Possible Interaction: Cysteine and Homocysteine

“Supplementation with cysteine or taurine, however, was found to be effective in reducing plasma homocysteine levels.”

“Conflicting reports exist in the literature concerning the relative influence of homocysteine and cysteine upon apoA-I expression.”

“SOD-catalyzed oxidation of GSH and homocysteine was enhanced by cysteine through a thiol-disulfide exchange mechanism.”

“Selective monitoring of Cys over its analogues homocysteine (Hcy) and glutathione (GSH) is of great significance.”

“The combined use of Cys C and Hcy further improves the predictive accuracy.”

“However, glutathione (GSH), homocysteine , N-acetyl-L-cysteine and other thiols greatly hamper the detection of Cys.”

“Furthermore, a positive correlation was found between Hcy and Cys and the presence of fibrosis in children with NAFLD.”

“A significant correlation was found between cysteine and homocysteine levels in patients with TA (ρ = 0.676, p < 0.0001), while there was no correlation between homocysteine and PON1 activity (ρ = 0.214, p = 0.265).”

“Intracellular cysteine is rate-limiting for synthesis of the antioxidant glutathione (GSH), and factors regulating cysteine uptake exert a powerful influence over cellular redox status, especially in mature neurons where cysteine synthesis via transsulfuration of homocysteine (HCY) is restricted.”

“However, only the combination of high tHcy and high ApoA-I had an increased risk for CAD (OR: 1.438, 95% CI (1.170-1.768)).ConclusionsThe association of homocysteine and cysteine , ApoA-I or HDL cholesterol and their joint effects provide new insights on its role on CAD.”