Possible Interaction: Cysteine and Histidine

“It catalyzes antiport of His and some neutral amino acids such as Ile, Leu, Val, Cys , Met, Gln and Phe thus being involved in amino acid metabolism.”

“The percentages of proteins, branched‐chain amino acids (leucine, isoleucine, and valine), histidine , and proline in eggs (albumen+yolk) showed a linear negative response in function of higher Met+Cys levels.”

“Substitution of the axial histidine ligand with cysteine increases the potential of P(700)(+)/P(700) to 583 mV and changes the rate of P(700)(+) reduction to 0.8 micros.”

“ Cysteine inhibited it more efficiently than histidine , methionine, tryptophan, tyrosine or alanine under the conditions used.”

“We demonstrate that the catalytic activity is based on an intermolecular cooperative behavior between histidine and cysteine.”

“Our results show that the cysteine ligand at the Mo ion is displaced by the formate substrate during the reaction, the arginine has a direct role in substrate binding and stabilization, and the histidine elevates the pKa of the active site cysteine.”

“In this work, it was discovered that in addition to catalyzing the oxidative coupling between histidine and cysteine (1 → 6 conversion), OvoA can also catalyze a direct oxidative coupling between hercynine (2) and cysteine (2 → 4 conversion), which can shorten the ergothioneine biosynthetic pathway by two steps.”

“Substitution of cysteine by histidine also induces an increase in the magnitude of the reaction energy barrier: It becomes 20.0 and 20.9 kcal mol(-1) for the CCCH and CCHH cores, respectively.”

“It is found that cysteine alone can repair the cis-O6mG to guanine, but the involvement of histidine along with cysteine lowers down the barrier energy significantly.”

“Competition experiments with dAMP, ribose monophosphate and histidine showed preferential coordination to the cysteine thiol over the phosphate(O) and heterocyclic(N) groups.”