Possible Interaction: Cysteine and Glyburide

“Pre-treatment of myometrium strips with glibenclamide , an inhibitor of ATP-sensitive potassium (KATP) channels, abolished the inhibitory effect of L-cysteine on spontaneous contraction amplitude.”

“ Glibenclamide (300 µM), an inhibitor of KATP channels blocked the inhibitory action of GYY 4137 and l-cysteine but not that elicited by N-acetylcysteine on K+-induced [3H]D-aspartate release.”

“This increase in outflow induced by l-cysteine was significantly (P < 0.001) antagonized by AOAA (30 μM) and glibenclamide (100 μM).”

“Both glibenclamide and capsazepine abolished l-cysteine and H(2)S donors' augmentation of gastric emptying.”

“Both the inhibitor of cystathionine β-synthase, AOA (30 μM) and the KATP channel antagonist, glibenclamide (100 μM) caused significant (P < 0.001) rightward shifts in the concentration-response curves to L-cysteine and attenuated the maximum inhibitory response.”

“Moreover, after preincubation of aged rat channels with 1 mM L-cysteine , the blocking effect of glybenclamide was reduced and was similar to that observed in young adult rat fibers.”

“The uptake of glibenclamide by pancreatic islets was inhibited by cysteine or reduced glutathione.”

“The observation of a reduced uptake of glibenclamide in the presence of cysteine raises the question whether sulfonylureas stimulate insulin release by reacting with sulf-hydryl groups in the /3-cell membrane.”