Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Cysteine and Glyburide

supplement:

Cysteine

Research Papers that Mention the Interaction

Pre-treatment of myometrium strips with glibenclamide , an inhibitor of ATP-sensitive potassium (KATP) channels, abolished the inhibitory effect of L-cysteine on spontaneous contraction amplitude.
PloS one  •  2011  |  View Paper
Glibenclamide (300 µM), an inhibitor of KATP channels blocked the inhibitory action of GYY 4137 and l-cysteine but not that elicited by N-acetylcysteine on K+-induced [3H]D-aspartate release.
Neurochemical Research  •  2018  |  View Paper
This increase in outflow induced by l-cysteine was significantly (P < 0.001) antagonized by AOAA (30 μM) and glibenclamide (100 μM).
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics  •  2017  |  View Paper
Both glibenclamide and capsazepine abolished l-cysteine and H(2)S donors' augmentation of gastric emptying.
European journal of pharmacology  •  2012  |  View Paper
Both the inhibitor of cystathionine β-synthase, AOA (30 μM) and the KATP channel antagonist, glibenclamide (100 μM) caused significant (P < 0.001) rightward shifts in the concentration-response curves to L-cysteine and attenuated the maximum inhibitory response.
Current eye research  •  2010  |  View Paper
Moreover, after preincubation of aged rat channels with 1 mM L-cysteine , the blocking effect of glybenclamide was reduced and was similar to that observed in young adult rat fibers.
Molecular pharmacology  •  1994  |  View Paper
The uptake of glibenclamide by pancreatic islets was inhibited by cysteine or reduced glutathione.
Endocrinology  •  1976  |  View Paper
The observation of a reduced uptake of glibenclamide in the presence of cysteine raises the question whether sulfonylureas stimulate insulin release by reacting with sulf-hydryl groups in the /3-cell membrane.
Pharmacology  •  1974  |  View Paper