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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cysteine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Cell culture studies demonstrate that supplementation with vitamin D and LC significantly increased GCLC expression and GSH formation in control and high-glucose-treated monocytes.”
“Therefore, different strategies to supplement cysteine supply have been suggested to increase glutathione levels in HIV‐infected individuals.”
Oral supplementation with whey proteins increases plasma glutathione levels of HIV‐infected patients“Analytical studies demonstrated that glutathionylated Mpro primarily exists as a monomer and that modification of a single cysteine with glutathione is sufficient to block dimerization and inhibit its activity.”
“Oral GSH greatly enhances the exposure of GSH, CYS , CYS-GLY, and γ-GC in rat duodenum, jejunum, ileum, and colon.”
“HIGHLIGHTSAddition of glutathione to cysteines alters the structure/function of a protein.”
“ Protein cysteines can form transient disulfides with glutathione (GSH), resulting in the production of glutathionylated proteins, and this process is regarded as a mechanism by which the redox state of the cell can regulate protein function.”
“The synthesis of glutathione , a major cellular antioxidant with a critical role in T cell proliferation, is limited by cysteine.”
Differential dependence on cysteine from transsulfuration versus transport during T cell activation.“However, brain glutathione declined 21% and brain cysteine increased 54%.”
“Treatment of HIT-T15 and RINm5F cells with l-cysteine or l-cystine significantly augmented the glutathione contents, surpassing the effect of N-acetylcysteine, and abrogated 4-hydroxy-2-nonenal-mediated cytotoxicity almost completely.”
“ l-Cysteine increased intracellular glutathione levels in primary beta-cells as well.”
“A decrease of cysteine may cause eye diseases, due to decrease in the synthesis of glutathione (antioxidant).”
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