Possible Interaction: Cysteine and Ferric Ion

“Taken together, these observations are evidence that cysteine and reduced N-terminal cysteine peptides are capable of enhancing iron uptake from soluble and insoluble ferric iron.”

“ Cysteine significantly increases, about 2-fold, the absorption from nonheme iron present in vegetable foods, hemosiderin, and of a ferric salt , when this amino acid is administered during the ingestion of foods.”

“The rates of degradation of NB were positively correlated with the range of concentrations of CYS from 0 to 10 mmol/L. The introduction of CYS increased the maximum concentration of Fe(III) by 12 times and that of Fe(II) by four times in this system.”

“The importance of cysteine in this process was confirmed by mutagenesis, which also showed that holo Fe(III) , but not Fe(II)-NO, H-NOX relied heavily upon cysteine for activation.”

“This study found that cysteine , a common aliphatic amino acid, can strongly enhance Fenton degradation of organic pollutants by accelerating Fe(III)/Fe(II) redox cycle , as quinone-hydroquinone analogues do.”

“In vitro analysis demonstrated that cysteine reduces ferric iron with exceptional speed.”

“The amount of Fe(III)-bleomycin formed after addition of ferric ions was markedly increased in the presence of ferric ion binding compounds (BSA, citrate) or reducing agents (ascorbate, cysteine).”