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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
drug:
Ethacrynic Acid
Research Papers that Mention the Interaction
“However, DNA binding of a Cys--> Ser p65 mutant was not inhibited by ethacrynic acid, suggesting that ethacrynic acid inhibits DNA binding by alkylating p65 at Cys.”
Ethacrynic acid inhibits multiple steps in the NF-kappaB signaling pathway.“The combination of ethacrynic acid and cysteine , itself an alkaline phosphatase inhibitor, is less inhibitory than ethacrynic acid alone.”
“ L-Cysteine , glutathione, verapamil or Ca(2+)-free solution significantly inhibited the contractions induced by ethacrynic acid or N-ethylmaleimide.”
A possible effect of sulfhydryl reagents on the contractile activity of the rat detrusor muscle.“Tissue electrolytes of inner medulla decreased much more in rats given ethacrynic acid plus cysteine.”
“We conclude that the addition of cysteine to intravenous infusion of ethacrynic acid greatly enhances its in vivo natriuretic potency in the rat.”
“ Cysteine and dithiothreitol, both disulphide reducing agents, prevented the effects of quercetin and ethacrynic acid , suggesting that sulphydryl groups may be important for the expression of Ca2+-ATPase activity.”
“In three monkeys simultaneous perfusion of ECA with cysteine in 10% excess prevented this effect.”
“Simultaneous perfusion of 0.1 mM ECA with 0.5 mM cysteine blocked this increase in facility.”
“ Cysteine added to the incubation medium partially blocked ATPase inhibition by either EA or the known sulfhydryl inhibitor, POMB.”
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