Possible Interaction: Cysteine and Edetic Acid

“The presence of EDTA significantly reduced intestinal Zn uptake to 11%, while cysteine improved it by 59%.”

“The chelating agents EDTA and EGTA were inhibitory, as were the thiol reagents dithiothreitol and cysteine.”

“Incubation of vesicles with a number of amino acids did not stimulate Pb++ uptake although two cysteine and glutathione) and the chelators EDTA or ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid) completely blocked this process.”

“The modification of the critical cysteines (two per myosin) inactivated the EDTA and Ca2+ ATPase activities, the latter to a lesser extent.”

“Modification of a single cysteine on subfragment one resulted in an inhibition of both the Ca2+ and the EDTA ATPase activities, but the latter always to a greater extent.”

“Calcium is required for activity; EDTA and cysteine are inhibitory.”

“In contrast, EDTA markedly inhibited the action of cysteine , glutathione, and an "insulin-like" factor from serum on fat cell glucose metabolism.”

“In fat cells incubated in a 3% albumin medium which had been incubated for 30 min with 2 mm cysteine prior to addition of EDTA and cells, EDTA was ineffective in blocking the action of cysteine.”

“The inhibition by EDTA was greater on high concentrations of cysteine (1.5 or 2 mm) than lower concentrations (0.5 or 1 mm).”

“Moreover, SDS and β-mercaptoethanol were inhibitory, and inhibition by L-cysteine was observed while EDTA and DMSO had almost no inhibitory effect.”

“Ferrous ion is required for activation in the presence of cysteine , and EDTA inhibits the activation process.”