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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cysteine
drug:
Disulfiram
Research Papers that Mention the Interaction
“The alcohol aversion drug disulfiram DSF ) reacts and conjugates with the protein-bound nucleophilic cysteines and is known to elicit anticancer effects alone or improve the efficacy of many cancer drugs.”
Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage.“Finally, we have exploited MRP4 (ABCC4) to demonstrate that disulfiram can inhibit ATP binding by forming disulfide bonds between cysteines located in the vicinity of, although not in, the active site.”
“Further mechanistic and kinetic studies indicated that disulfiram reacts irreversibly with the active site cysteine residue of NAT1, leading to its rapid inhibition (IC50 = 3.3 ± 0.1 μm and ki = 6 × 104 m−1·min−1).”
“As a consequence, GSH and sulfhydryl groups of protein cysteines in human platelets, in analogy to other components of human blood, are a potential target of disulfiram.”
“Succinic semialdehyde dehydrogenase and aldehyde dehydrogenase (EC 1.2.1.3) were also inhibited by disulfiram ; their activity could be regained with 2-mercaptoethanol but not with 33 microM cysteine or glutathione.”
“In patients on disulfiram , but not the healthy controls, plasma cysteine decreased significantly.”
“ Disulfiram pretreatment reduced 24 hour urinary excretion of acetaminophen-mercapturate and- cysteine while excretion of -sulfate and -glucuronide was unchanged.”
Disulfiram prevents acetaminophen hepatotoxicity in rats.“ Disulfiram (Antabuse, tetraethylthiuram) inhibits DNA cleavage by 1,2-dimethylhydrazine, ascorbate and cysteine.”
Disulfiram inhibits DNA breakage by hydroxyradical-producing agents.
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