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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Cysteine
drug:
Darinaparsin
Research Papers that Mention the Interaction
“In vivo, the propensity of As(III) species to bind to unfolded cysteine-containing proteins may contribute to oxidative and protein folding stresses that are prominent features of the cellular response to arsenic exposure.”
Arsenic(III) species inhibit oxidative protein folding in vitro.“The addition of exogenous GSH, l-cysteine , or d-cysteine prevented darinaparsin cellular uptake and cell death but had no effect on the uptake or activity of arsenic trioxide, suggesting a difference in the transport mechanism of these two drugs.”
“Mutagenesis of five other cysteines in Acr3p resulted in moderate reduction of As(III) transport capacities and sorting perturbations.”
Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces cerevisiae.
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