Possible Interaction: Cysteamine and Cysteine

“We conclude that cysteamine depletes lysosomes of cystine by participating in a thiol-disulphide interchange reaction to produce cysteine and cysteine-cysteamine mixed disulphide, both of which traverse the cystinotic leucocyte lysosomal membrane.”

“The combined use of cysteine and mercaptoethylamine (6) or cysteine and sodium nitrite (7) in rodents has provided greater protection against radiation than either agent alone.”

“ Cysteinamine and cysteine appear to be additive in their protective effect against acute radiation lethality.”

“Both of these effects of MEA were completely reversed by 0.3-mmol dm-3 Cys.”

“If cysteine (Cys) at low concentrations was added at the same time as MEA it counteracted the action of MEA.”

“The effect of MEA may be described as a competitive inhibition of an inducing or conducting effect of Cys.”

“This effect, which may be counteracted by cysteine , indicates that in general MEA inhibits the induction of SOS functions.”

“In model experiments it was shown that cysteine counteracted the inhibition by MEA of beta-galactosidase induction in both bacterium strains.”

“The comutagenic action of MEA was eliminated by cysteine at low concentrations, which also lowered mutation frequencies in AB1157 but not in ada-6.”

“ Cysteine slightly accelerates the decrease in all three buffers and partially antagonizes the effect of mercaptoethylamine.”

“ Mercaptoethylamine inhibits the induction of the enzyme for the oxidation of benzoate, and cysteine does this less effectively.”

“Combinations of cysteine with mercaptoethylamine or glutathione were more effective in preventing HN2-induced mortality than when these sulfur-containing compounds were administered alone.”