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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cysteamine
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Azide and cyanide greatly increased the level of damage; sulfhydryl compounds (glutathione, cysteine, and cysteamine ) and ascorbate markedly decreased the level of damage.”
Factors which affect DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate.“In mouse spleen lymphocytes stimulated by concanavalin A in vitro, MEA and ascorbate exhibited a strong antagonism, neutralizing each other's inhibitory action on RNA synthesis.”
“The latter effect failed to appear after chelation of trace metals, and it is indicated that the ability of ascorbate to counteract the effects of MEA on radiosensitivity and metabolism requires the formation of oxidized products, probably monodehydroascorbate, in agreement with previous observations on bacteria.”
Interaction of ascorbate with the radioprotective effect of mercaptoethylamin. An exploratory study in mice, whole animals and cell cultures.“Cystamine as well as cysteamine prevented the loss of proteins from mitochondria induced by ascorbate , whereas cadaverine, GSSG and GSH were inefficient.”
“1953) demonstrated a large fall in adrenal ascorbate after administration of 2-aminoethanethiol (cysteamine) but no change in cholesterol content.”
“Our earlier finding that the radioprotective action of 2-mercaptoethylamine MEA ) is counteracted by ascorbate suggests a biochemical mechanism of action, which is supported by observations that MEA is not radioprotective in Rec- E. coli strains.”
Inhibition of recA induction by the radioprotector 2-mercaptoethylamine.
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