Possible Interaction: Cyproheptadine and Glucose

“ Cyproheptadine did not affect the hunger rating, nor the affective rating in fasted subjects, but it reduced significantly the negative alimentary alliesthesia induced by the glucose load.”

“The insulin response to a glucose load either i. v. or orally was found to be blunted after one month of treatment with a low dose of cyproheptadine.”

“Hexamethonium, cyproheptadine , and atropine partially blocked the CRF response to 0.55 mM glucose.”

“3 Cyproheptadine completely inhibited Ca2+ uptake induced by d‐glucose and high K+o, two agents which depolarize the islet β‐cell membrane, whilst Ca2+ uptake elicited by removal of extracellular Na+ (i.e. Na+‐Ca2+ counter transport) was only slightly reduced.”

“Injections of propranolol, hexamethonium, and cyproheptadine inhibited the 5‐HT‐induced increase in glucose but not in cAMP.”

“ Cyproheptadine , in contrast to other antagonists employed, induced large increases of insulin, glucagon and glucose , although this hyperinsulinemia was of a smaller magnitude when compared with hormone levels observed during an equivalent hyperglycemia resulting from glucose administration.”

“The pancreatic response to a glucose load (increased insulin and decreased glucagon release) and an arginine load (increased insulin and glucagon release) were prevented by cyproheptadine pretreatment.”

“ Cyproheptadine (1, 10 and 100 muM) significantly reduced insulin release from isolated mouse islets in response to glucose.”