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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyproheptadine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“When the calcium concentration of the medium was enhanced, the inhibitory effect of cyproheptadine was still visible, although the relative inhibition had become smaller.”
Inhibition of insulin and glucagon release from the perfused rat pancreas by cyproheptadine (Periactinol®, Nuran®)“Lowe et al 4 concluded that cyproheptadine reduced the flow of calcium ion through the voltage-dependent calcium channels in guinea pig smooth muscle.”
“ Cyproheptadine is equipotent (IC50 = 41 to 45 nM) in blocking contractions of canine basilar artery segments induced by serotonin, norepinephrine, potassium, or calcium.”
“1 The ability of cyproheptadine (Cph) to inhibit membrane translocation of calcium in smooth muscle was investigated by studying the drug's action on contraction, electrical activity and calcium influx in the guinea‐pig taenia coli.”
“These inhibitory effects of Cph were antagonized by increasing the medium [ Ca ] three fold to 7.68 mM. 3 Intracellular recordings showed that Cph>2 × 10−6M decreased the amplitude and extended the duration of the action potential.”
“5 These results suggest that cyproheptadine inhibits depolarization‐dependent calcium entry into pancreatic β‐cells.”
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