Possible Interaction: Cyclosporine and Vitamin E

“Noncompartmental pharmacokinetic analysis showed that coadministration of vitamin E TPGS increased the oral bioavailability of Sandimmune.”

“ alpha-Tocopherol (32 microM) almost completely prevented cell death due to either CsA or tamoxifen.”

“In contrast, we found that vitamin E enhanced HCV RNA replication and negated the effects of the three anti-HCV nutrients and cyclosporine but not those of interferon or fluvastatin.”

“A similar polyoxyl hydrogenated castor oil, Cremophor EL (BASF), a vehicle for intravenous drugs such as paclitaxel and cyclosporine, was found to inhibit P-glycoprotein, and a water-soluble form of vitamin E (d-alpha tocopherol polyethylene glycol 1000 succinate) has been shown to increase cyclosporine concentrations.”

“The tendency for a lower reduction in RPF and GFR following CsA during the vitamin E period in healthy humans warrants additional studies in transplant patients.”

“Furthermore, administration of PEG‐SOD clearly attenuated TGF‐&bgr;/Smad signaling induced by CsA. Moreover, concomitant administration of Vit E along with CsA significantly ameliorated the histopathological changes and improved liver function as well as the antioxidant capacity.”

“Pretreatment of animals with Vitamin E (Vit E) before CsA administration significantly reduced TGF‐&bgr; level as well as Smad phosphorylation and subsequent CTGF and TIMP‐1 expression.”

“In conclusion, dietary supplementation with alpha-tocopherol and alpha-lipoic acid enhanced the erythrocyte antioxidant defence and reduced nephrotoxicity in cyclosporine treated animals.”

“In summary, dietary supplementation with α‐tocopherol and α‐lipoic acid attenuated the cyclosporine‐induced decrease in erythrocyte superoxide dismutase activity and attenuated cyclosporine‐induced vascular dysfunction.”

“ Vitamin E also decreased the fall in pancreatic weight observed in Cr + CsA pancreas.”

“ Vitamin E inhibits TGF-beta release in mesangial cells and reduces CsA cytotoxicity.”

“As antioxidant, Vitamin E (VitE) has been used to diminish the toxicity of CsA in vitro.”

“However, when hepatocytes were coincubated with CsA and VitE , an increase in the expression and activity in all antioxidant enzymes (MnSOD, CuZnSOD, catalase and GPx) was observed.”