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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cyclosporine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Supplementation with anti-oxidants Vitamin C and E decreases cyclosporine A trough-levels in renal transplant recipients.”
Registry of randomized controlled trials in transplantation: January 1 to June 30, 2006.“Interaction of vitamin C and cyclosporine is the most important interaction with post-renal transplant medications.”
“ CsA administration induced significant elevation in lipid peroxidation along with abnormal levels of enzymic (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase) and non-enzymic antioxidants (glutathione, vitamins C and E) in the rat kidney.”
Role of lipoic acid in reducing the oxidative stress induced by cyclosporine A.“…,ascorbic acid (… CsA (0.01–1.0 μM) and the toxic effect of 10.0 μM CsA. Pre‐treatment with CsA at concentration of 0.01–…‐induced cardiomyocyte apoptosis not only by preventing the loss of ΔΨm in mitochondria, but also through ROS generation, Hsp70, and iNOS up‐regulation.”
“ CsA also decreased the level of endogenous antioxidant ascorbic acid and increased its oxidation product dehydroascorbic acid.”
“Supplementation of the cell cultures with ascorbic acid significantly reduced the CsA toxicity.”
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