supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago
drug:
Cyclosporine
supplement:
Taurine
Research Papers that Mention the Interaction
“Identical activity is seen upon treatment of isolated mitochondria with TN-Cl and is blocked by the permeability transition pore inhibitors bongkrekic acid and cyclosporin A , as well as by the sulfhydryl-reducing agent tris(2-carboxyethyl)-phosphine.”
Taurine chloramine, an oxidant derived from neutrophils, induces apoptosis in human B lymphoma cells through mitochondrial damage.“ CsA treatment reduced both the taurine uptake and the relative surface abundance of the transporter by similar magnitudes.”
“ Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria.”
The effect of taurine on the ion transport system in mitochondria“ Taurine markedly reduced elevated blood pressure, attenuated renal dysfunction and the reduction in serum NO levels and counteracted the deleterious effects of CsA on oxidative stress markers.”
“These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback