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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Cyclosporine
supplement:
Taurine
Research Papers that Mention the Interaction
“ CsA treatment reduced both the taurine uptake and the relative surface abundance of the transporter by similar magnitudes.”
“These results suggested that the CsA inhibited taurine transport by altering the surface abundance, possibly by internalization of the expressed taurine transporters.”
Inhibition of taurine transport by cyclosporin A is due to altered surface abundance of the taurine transporter and is reversible.“Pre-incubation with cyclosporine A (5 μM) inhibited [3H] taurine uptake by 29.3%-5.3% (n = 8, P < .05, paired Student t test).”
“ Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria.”
The effect of taurine on the ion transport system in mitochondria“4 Taurine markedly reduced elevated blood pressure, attenuated renal dysfunction and the reduction in serum NO levels and counteracted the deleterious effects of CsA on oxidative stress markers.”
“These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.”
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