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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Cyclosporine and Taurine



Research Papers that Mention the Interaction

Identical activity is seen upon treatment of isolated mitochondria with TN-Cl and is blocked by the permeability transition pore inhibitors bongkrekic acid and cyclosporin A , as well as by the sulfhydryl-reducing agent tris(2-carboxyethyl)-phosphine.
The Journal of biological chemistry  •  2005  |  View Paper
CsA treatment reduced both the taurine uptake and the relative surface abundance of the transporter by similar magnitudes.
Advances in experimental medicine and biology  •  2009  |  View Paper
Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria.
Biofizika  •  2008  |  View Paper
Taurine markedly reduced elevated blood pressure, attenuated renal dysfunction and the reduction in serum NO levels and counteracted the deleterious effects of CsA on oxidative stress markers.
Clinical and experimental pharmacology & physiology  •  2006  |  View Paper
These results indicate that taurine has a protective action against CsA hepatotoxicity and suggest that taurine may find clinical application against a variety of toxins where cellular damage is a consequence of reactive oxygen species.
Toxicology letters  •  2004  |  View Paper